Human Therapeutics

Chlorogen will leverage the unique expression and production capabilities of its CTT™ platform to penetrate the human therapeutics markets. This will be achieved by developing proprietary genes supplied by select collaborators and co-developing products with biotechnology and major pharma players. Partnering in this way will allow Chlorogen to focus on its strengths while leveraging the strength of its partners to access the marketplace.

Chlorogen Products

Chlorogen’s first product in the pipeline is a member of the TGF-ß superfamily. The TGF-ß superfamily encompasses a large group of soluble extracellular proteins that are potent regulators of embryonic and adult tissues. They can direct a wide range of cellular responses including proliferation, apoptosis, cellular maturation, organogenesis and tissue homeostasis.
      The primary indications for Chlorogen's first product are gynecologic cancers. In vitro and in vivo tests of the protein demonstrate efficacy against breast, prostate, ovarian, cervical and possibly endometrial cancers. This product has the potential to save many lives, as new cases of these cancers in the U.S. and Europe total nearly one million per year. Uterine and ovarian cancers are generally discovered in later stages, when the survival rates are much lower, in the range of 12 to 31 percent. These are candidates for orphan drug designations and will be Chlorogen’s initial focus. Chlorogen anticipates entering clinical trials with this product in 2009-2010.
      Chlorogen's ability to produce an apoptosis-inducing member of the TGF-ß super-family of proteins is groundbreaking proof-of-concept work that is expected to lead to several other new commercial product candidates.

Other pharma applications

CTT™ has been shown to be technology that is widely applicable and capable of producing several types of products. In addition to our current pipeline, Chlorogen has also expressed a vaccine for cholera, human serum albumin for therapeutic and non-therapeutic applications, interferon for liver diseases including hepatitis C and insulin-like growth factor for diabetes and other diseases.